TY  - THES
T1  - Film forming polymeric solutions as drug delivery systems for the skin
A1  - Zurdo Schröder,Ines
Y1  - 2007/03/12
N2  - The aim of this thesis was to develop and investigate film forming polymeric solutions as a novel delivery system for the skin. These solutions form very thin, flexible and almost invisible films on the skin which can serve as a reservoir for the transdermal delivery of drugs. In a first step various excipients were studied and formulation experiments were performed to provide the technological basis for the new delivery system. Compositions with different polymers were identified that provided suitable properties for the intended application (short drying time, low viscosity, permanence on the skin). Methods for the evaluation and characterization of the novel dosage form were developed and assessed. The drug delivery from the film forming systems through human epidermis was investigated with caffeine as model drug and steroidal hormones as therapeutically relevant compounds. The impact of different parameters on the drug permeation from the polymeric system was tested. Among these parameters were the nature of the solvent, the drug concentration or the incorporation of chemical enhancers. Finally, comparative in vitro and in vivo studies with registered transdermal patches were carried out to assess the drug delivering potential of the new dosage form for steroidal hormones. The obtained results have demonstrated that film forming polymeric solutions are a promising approach for transdermal drug delivery that should be pursued further in the future.
KW  - Haut
KW  - Therapeutisches System
KW  - Filmbildung
KW  - Polymerlösung
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2007/1044
ER  -