TY  - THES
T1  - Human skin drug delivery using biodegradable PLGA-nanoparticles
A1  - Luengo Contreras,Javiana Elizabeth
Y1  - 2007/05/07
N2  - During the last years transdermal drug delivery has gained increasing interest due to the high acceptance of patients. However the major problem of drug delivery via the cutaneous route are the barrier properties of the skin which are located in the stratum corneum. To study the potential of polymeric biodegradable nanocarriers on drug delivery to and through the skin  the well known biodegradable copolymer poly(D,L-lactide-co-glycolide) (PLGA 50:50) was used as main component of the carrier system. As model drug  flufenamic acid, an antiinflamatory drug, was incorporated. Nanoparticles in the size range of 200 to 400 nm were prepared by means of a solvent extraction technique. In vitro skin transport experiments using Franz diffusion cell systems and the Saarbrücken model showed an enhancement effect for encapsulated flufenamic acid independent of particle size. Surprisingly, also the presence of drug-free nanoparticles in a preparation (hydrogel) with flufenamic acid in solution has also increased the permeated amount of drug. As mechanism of action an acidic nano-environment around the particles could be identified by confocal laser scanning microscopy and permeation experiments using buffered and non-buffered preparations. Other studies have shown that nanoparticles were able to penetrate into the hair follicles when massage was used. These results underscore the potential of polymeric biodegradable nanoparticles as carriers for transdermal drug delivery. Especially, the acidic pH of the nano-environment of the particles might be an advantage to develop special formulations designed for acidic drugs or might be used to re-establish the physiological acidic pH on the skin surface.
KW  - Nanopartikel
KW  - Biologischer Abbau
KW  - Haut
KW  - In vitro
KW  - Permeation
KW  - Penetration
KW  - Arzneistoffträger
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2007/1118
ER  -