TY  - THES
T1  - Myxococcus xanthus - a myxobacterial model strain as multiproducer of secondary metabolites
A1  - Meiser,Peter
Y1  - 2008/09/04
N2  - Within the last three decades, myxobacteria have been established as proficient producers of secondary metabolites that exhibit various biological activities. The recently finished genome sequencing project of Myxococcus xanthus DK1622 unveilled the — at least hypothetical — potential of this myxobacterial model strain to be a multiproducer of secondary metabolites as well. Applying a combined genetic and analytical approach, indeed several natural products and the corresponding biosynthetic gene clusters were identified and analyzed in our institute. Among them, four families of metabolites — myxochelins, myxochromids, myxalamids and myxovirescins — were already known from other myxobacterial species. The DKxanthene secondary metabolite family, however, resembles a novel class of compounds that appears to be unique to myxobacteria, and they were shown to be present in all Myxococcus xanthus strains investigated to date as well as in the closely related species Stigmatella aurantiaca. Studies aiming at the investigation of the biological function of these compounds strongly suggest that they are required for a proper progress of the developmental program that culminates in the formation of fruiting bodies and mature myxospores. DKxanthenes are synthesized by a hybrid polyketide synthase - nonribosomal peptide synthetase machinery, and the detailed analysis of the biosynthetic gene cluster proposes the presence of at least one iteratively acting polyketide synthase module that is in large part responsible for the diversity of metabolites from this family.
KW  - Bakterien
KW  - Myxobakterien
KW  - Myxococcus xanthus
KW  - Sekundärmetabolit
KW  - Biotechnologie
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2008/1683
ER  -