TY  - THES
T1  - Heme-iron complexing biphenyl and naphthalene derivatives as CYP17 inhibitorsfor the treatment of prostate cancer : design, synthesis and evaluation
A1  - Pinto-Bazurco Mendieta,Mariano Aurelio Ernesto
Y1  - 2009/11/30
N2  - Insufficient efficacy and unsafe treatment options are the current state of the art of prostate cancer therapies. This motivated us to develop antiandrogenic drugs with reduced side effects, aiming at effective tumor growth prevention and regression for prostatic adenocarcinomas. The key enzyme in androgen synthesis CYP17 is to date the most promising target for an overall, mild treatment of prostate carcinomas. Thus, it was our aim to develop nonsteroidal CYP17 inhibitors. In the present work, the synthesis, biological evaluation and molecular modeling studies of 69 compounds divided in three main classes are presented. These were published in three different international scientific magazines. A further manuscript is already prepared. Other related compounds, not essential for this work, are already published or to be published soon in four other co-authored works.
KW  - Pharmazie
KW  - Prostata
KW  - Krebsforschung
KW  - Design
KW  - Synthese
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2009/2147
ER  -