TY  - THES
T1  - Stress activated protein kinase : central mediator of stress- and infection-induced changes in sensory processing, learning and memory in honeybee (Apis mellifera)
A1  - Iqbal,Javaid
Y1  - 2009/06/30
N2  - My work demonstrates a central role of JNK (Jun-N-terminal kinase), well known as central component in mammalian immune and stress response, in sensory processing and associative learning in honeybees. I describe the implication of JNK in mediating changes in behaviour induced by deformed wing virus (DWV) infection, and two other stress stimuli (UV light; UV and shaking with light; SL). DWV infected honeybees (3 days after infection) show changes in sensory processing, an impaired associative learning and memory formation, but intact non-associative learning. DWV infection activates JNK in a complex temporal pattern in the mushroom bodies (MBs) and acts via transcription to induce changes in behaviour. Interestingly, short-term UV exposure (≥15 min) and long-term SL treatment (overnight) induce similar behavioural changes as virus infection and lead to JNK activation in the brain. Inhibition of JNK fully restores stress induced biochemical as well as behavioural changes. UV induced behavioural changes require transcription while SL induced behavioural changes does not require transcription. Experiments on isolated Drosophila Kenyon cells show that UV light has an inhibitory effect on neuronal transmission and points to the MBs as the cellular location of stress induced physiological changes. Taken together, my data provide first evidence that JNK acts as central mediator between stress and behaviour of honeybee.
KW  - Lernen
KW  - Assoziatives Gedächtnis
KW  - Stress
KW  - Virusinfektion
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2009/2238
ER  -