TY  - THES
T1  - Natural and synthetic flavonoid derivatives with potential antioxidant and anticancer activities
A1  - Mohammed,Hamdoon
Y1  - 2009/12/03
N2  - Flavonoids form a family of well known natural products present in most of the plant families. More than 8000 different flavonoids have been isolated from their natural source to date. The structural variations of these flavonoids are associated with many different biological and pharmacological activities, including anticancer activity, protection against cancer formation (chemo-protection), antioxidant activity, cardiovascular and hepatic protection, antibacterial, antifungal and antiviral activity. Flavonoids have also been reported to play an important role in hormone-related female diseases, such as breast cancer and menopausal syndrome. Natural flavonoids have therefore been subjected to many chemical modifications in order to improve their activity. As part of this thesis, I have added moieties such as an amino alkyl chain, selenium and tellurium containing moieties. As part of an approach to generate flavonoid derivatives more active and specific toward cancer cells, addition of a chromene ring (ring D) to the flavonoid core structure resulted in chromeneflavone derivative. Aromatase is a group of cytochrome P450 enzymes responsible for the biosynthesis of estrogen, the main stimulant of breast cancer cell growth. Some of the flavonoid derivatives tested (natural as well as synthetic) turned out to be good aromatase inhibitors and may be studied further in the treatment of breast cancer. Ten natural products in addition to 38 synthetic flavonoid derivatives were subjected to various in vivo and in vitro bioassays in order to understand the various antioxidant, cytotoxic and aromatase inhibiting properties associated with these compounds.
KW  - Flavonoide
KW  - Derivate
KW  - Antioxidans
KW  -  Aromatase
KW  - Aromatasehemmer
KW  - Cytostatikum
KW  - Cytotoxin
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2009/2620
ER  -