TY  - THES
T1  - Grafting polyacrylates from carbohydrates by ATRP and formation of nanoparticles for advanced drug delivery
A1  - Hirosue,Masayuki
Y1  - 2010/11/02
N2  - The present thesis describes synthesis and characterization of graft copolymers from carbohydrates and formulation of nanoparticles(NP)s for drug carrier application. Side chains were produced grafting from carbohydrate based macroinitiators via Atom Transfer Radical Polymerization (ATRP). Firstly, hydrophobic homo-, random- and block-copolymer side chains were grafted from a beta-Cyclodextrin core, followed by starch as a core. Monomer conversions up to 80% were achieved in most cases and well controlled polymers were obtained. Ni(II) triphenylphosphine complexes were found to be catalysts superior to the well known Cu(I) complexes, because they can be removed much easier from the product after polymerization.
NPs prepared by the emulsion-diffusion technique showed particle sizes of <200 nm, uniform shape and narrow size distribution (PDI<0.1). Not only the production parameter of NPs but also the chemical properties of the polymer influence the stability and size distribution of NPs. Especially the hydrophobicity of polymers and the composition of the arm of polymers (block or random) have a big influence on the stability and PDI of NPs. Since cell viabilities remain unaffected by these NPs, they are good candidates for the delivery of drugs. In conclusion, hydrophobically modified carbohydrate derivatives have a potential to serve as a new platform for biodegradable and biocompatible nano carriers.
KW  - Makromolekulare Chemie
KW  - Naturstoffchemie
KW  - Biopharmazie
KW  - Pharmazeutische Technologie
KW  - Pfropfcopolymere
KW  - Polyacrylate
KW  - Wirkstofffreisetzung
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2010/3397
ER  -