TY  - THES
T1  - Asymmetric particles for pulmonary drug delivery
A1  - Kohler,Dorothee Anna Luise
Y1  - 2011/01/28
N2  - Targeted drug delivery and controlled release are current challenges in pulmonary drug delivery. The deposition pattern and clearance from deposition site are two key parameters for drug delivery carrier design. Asymmetric particles allow an increase in peripheral drug delivery compared to spherical particles and furthermore, affect particle clearance mechanisms from the lung. Therefore, the main aim of this thesis was to develop new synthesis strategies to produce well-dispersible, biocompatible, biodegradable microfibers with a variety of aspect ratios and porosities. The macrophage response to the resulting microfibers was investigated. The aerosolization properties of the resulting microfibers were examined. From the obtained results it can be concluded that:
1. A new template-assisted synthesis strategy to produce monodisperse microfibers with defined dimensions has been developed.
2. The technique has been extended to various materials and process parameters for cell testing, drug loading and aerosolization tests.
3. Microfibers were successfully taken up by macrophages, only when they were approached from the pointy end.
4. Aerosolization studies showed good dispersion properties of microfibers with relatively high fine particle fractions.
In summary, this new technique may allow to produce microfibers for pulmonary drug delivery, which will lead to a better understanding of their in vivo behaviour such as mucoadhesion, macrophage interaction and deposition behaviour.

KW  - Mikrofaser
KW  - Makrophage
KW  - Lunge
KW  - Aerosolisierung
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2011/3532
ER  -