TY  - THES
T1  - On biophysical aspects of growth and dynamics of epithelial tissues
A1  - Streichan,Sebastian J.
Y1  - 2011/11/23
N2  - A fundamental and unresolved question of life is how organs are formed. The shape and form of organs emerges by spatio temporally controlled division and motility of cells. As both processes are tightly coordinated, interactions amongst cells are required to ensure stability and integrity. Many genetic networks controlling the polarised cell motility or promoting cell division have been identified. Action between cells results in an increased complexity. Yet cells give rise to regular patterned organs. The form of objects and their motion is subject to physical laws. Cells are of an active character, divide and move, interesting properties for a material, with potentially new knowledge emerging from their study. Here, we perform a quantitative characterisation of two experimental models for tissue morphogenesis. Using cultured epithelial sheets we address the mechanical properties of growth control and identify regulatory mechanisms. Based on this study, we propose a phenomenological description of tissue dynamics, reproducing the observed data. Using the methods developed to understand the cultured sheet, we approach the role of mechanics in the migration of an embryonic tissue. We measure the directed motion of the tissue and show that the findings can be reproduced by coupling the biophysical model of motile cells to a dynamically regulated polarisation mechanism.
KW  - Zellteilung
KW  - Migration <Biologie>
KW  - Nichtgleichgewichtsstatistik
KW  - Zellzyklus
KW  - Wundheilung
KW  - Organogenese
KW  - Chemotaxis
KW  - Actin
KW  - Elastische Spannung
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2011/4469
ER  -