TY  - THES
T1  - Evaluation of finite dose skin absorption experiments with respect to experimental setup and mathematical modelling
A1  - Hahn,Tsambika
Y1  - 2012/01/20
N2  - In this thesis finite dose skin absorption experiments were evaluated with respect to experimental setup and mathematical modelling. To increase the comparability between experiment and modelling, the experiments need to be carefully assessed. Thus, the use of infrared densitometry was judged suitable to quantify SC on tape-strips in vitro to increase the accuracy of the obtained concentration depth profiles in the SC. In vivo, usually a small dose of the formulation is applied to the skin, a so-called finite dose. Finite dose skin absorption experiments were performed, which are closer to the in vivo reality. The influence of non-homogeneous donor surface distribution was investigated with respect to the permeated drug amount as this had not been done before. A dependence on the physicochemical parameters of the drug was found. With the knowledge obtained before, finite dose skin penetration experiments were performed. The experimental data was analyzed with different mathematical models. A pharmacokinetic model developed for this study could describe the mass profiles in all compartments well, even in the lateral skin part. A 2D diffusion model previously developed for infinite dose and adapted to finite dose could predict the mass profiles and concentration depth profiles of finite dose experiments for the model drugs caffeine and flufenamic acid reasonably.
KW  - Hautresorption
KW  -  Mathematisches Modell
KW  - Arzneimitteldosis
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2012/4575
ER  -