TY  - THES
T1  - Chemotaxonomic investigations on resins of the frankincense species Boswellia papyrifera, Boswellia serrata and Boswellia sacra, respectively, Boswellia carterii : a qualitative and quantitative approach by chromatographic and spectroscopic methodology
A1  - Paul,Michael
Y1  - 2012/12/03
N2  - Extracts from the resin exudates of the frankincense tree again returned into the focus of pharmacological research within the last 20 years. So far, several research groups reported on promising anti-inflammatory, anti-microbial and even anti-tumour effects (in vitro and in vivo). The Boswellic acids are regarded as one of the most potent active agents thereof. However, the resins still contain innumerable amounts of terpenoid compounds. Their interactions, when administered as an extract, are not really understood hitherto. In addition, the information given in literature as to which molecular entity refers to which species has not been clearly verified in several publications. Thus, this work reports on qualitative and quantitative analytical methods (LC, GC, TLC, MS and NMR), which enable the unequivocal identification of the common incense species Boswellia papyrifera (Eritrea, Ethiopia), Boswellia serrata (India) and Boswellia sacra (Oman, Yemen), respectively, Boswellia carterii (Somalia). Based on these results, a general, though not yet empirically verified, hypothesis on the biosynthetic routes has been postulated. Besides, a partial-synthetic method for the enrichment of one compound (Incensole acetate) was developed. In cooperation with Prof. Werz (Jena) a few of the isolated compounds were tested to evaluate their pharmacological potential. The results delivered evidence on possible synergistic effects which were partly based on decompositions of single molecules.

KW  - Weihrauchstrauch
KW  - Chemotaxonomie
KW  - Isolierung <Chemie>
KW  - Strukturaufklärung
KW  - Chromatographie
CY  - Saarbrücken
PB  - Universitäts- und Landesbibliothek
AD  - Postfach 151141, 66041 Saarbrücken
UR  - http://scidok.sulb.uni-saarland.de/volltexte/2012/4999
ER  -