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URN: urn:nbn:de:bsz:291-scidok-14967

Effect of transforming growth factor-ß1 (TGF-ß1) released from a scaffold on chondrogenesis in an osteochondral defect model in the rabbit

Cucchiarini, Magali ; Sohier, Jerome ; Mitosch, Karin ; Kaul, Gunter ; Zurakowski, David ; Bezemer, Jeroen M. ; Kohn, Dieter ; Madry, Henning

Quelle: (2006) Central european journal of biology. - 1. 2006, 1, S. 43-60
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Institut: Fachrichtung 2.16 - Orthopädie
DDC-Sachgruppe: Biowissenschaften, Biologie
Dokumentart: Aufsatz
Sprache: Deutsch
Erstellungsjahr: 2006
Publikationsdatum: 23.04.2008
Kurzfassung auf Englisch: Articular cartilage repair might be stimulated by the controlled delivery of therapeutic factors. We tested the hypotheses whether TGF-ß1 can be released from a polymeric scaffold over a prolonged period of time in vitro and whether its transplantation modulates cartilage repair in vivo. Unloaded control or TGF-ß1 poly(ether-ester) copolymeric scaffolds were applied to osteochondral defects in the knee joints of rabbits. In vitro, a cumulative dose of 9 ng TGF-ß1 was released over 4 weeks. In vivo, there were no adverse effects on the synovial
membrane. Defects treated with TGF-ß1 scaffolds showed no significant difference in individual parameters of chondrogenesis and in the average cartilage repair score after 3 weeks. There was a trend towards a smaller area (42.5 %) of the repair tissue that stained positive for safranin O in defects receiving TGF-ß1 scaffolds. The data indicate that TGF-ß1 is released from emulsioncoated scaffolds over a prolonged period of time in vitro and that application of these scaffolds does not significantly modulate cartilage repair after 3 weeks in vivo. Future studies need to address the importance of TGF-ß1 dose and release rate to modulate chondrogenesis.

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