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URN: urn:nbn:de:bsz:291-scidok-15058

Advances in in vitro and in vivo models for studying the staphylococcal factors involved in implant infections

Harraghy, Niamh ; Seiler Sarah ; Jacobs, Karin ; Hannig, Matthias ; Menger, Michael D. ; Herrmann, Mathias

Quelle: (2006) The international journal of artificial organs. - 29. 2006, 4, S. 368 -378

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Institut 1: Fachrichtung 2.9 - Chirurgie
Institut 2: Fachrichtung 2.21 - Zahn-, Mund- und Kieferheilkunde
Institut 3: Fachrichtung 2.24 - Medizinische Mikrobiologie und Hygiene
Institut 4: Fachrichtung 7.2 - Experimentalphysik
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Deutsch
Erstellungsjahr: 2006
Publikationsdatum: 29.04.2008
Kurzfassung auf Deutsch: Implant infections due to staphylococci are one of the greatest threats facing patients receiving implant devices. For many years researchers have sought to understand the mechanisms involved in the adherence of the bacterium to the implanted device and the formation of the unique structure, the biofilm, which protects the indwelling bacteria from the host defence and renders them resistant to antibiotic treatment. A major goal has been to develop in vitro and in vivo models that adequately reflect the real-life situation. From the simple microtiter plate assay and scanning electron microscopy, tools for studying adherence and biofilm formation have since evolved to include specialised equipment for studying adherence, flow cell systems, real-time analysis of biofilm formation using reporter gene assays both in vitro and in vivo, and a wide variety of animal models. In this article, we discuss advances in the last few years in selected in vitro and in vivo models as well as future developments in the study of adherence and biofilm formation by the staphylococci.

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