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URN: urn:nbn:de:bsz:291-scidok-15063

Gene therapy for articular cartilage repair

Trippel, Stephen ; Cucchiarini, Magali ; Madry, Henning ; Shi , S. ; Wang, C.

Quelle: (2007) Proceedings of the Institution of Mechanical Engineers / H. - 221. 2007, 5, S. 451-459
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Institut: Fachrichtung 2.16 - Orthop├Ądie
DDC-Sachgruppe: Medizin
Dokumentart: Aufsatz
Sprache: Deutsch
Erstellungsjahr: 2007
Publikationsdatum: 29.04.2008
Kurzfassung auf Englisch: Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells'; degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage.
Keywords: gene therapy, vectors, articular cartilage, arthritis, animal models

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