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doi:10.22028/D291-36827
Titel: | Tissue Regeneration through Cyber‐Physical Systems and Microbots |
VerfasserIn: | Kumar, Prasoon Mirza, Khalid Baig Choudhury, Kaushik Cucchiarini, Magali Madry, Henning Shukla, Pratyoosh |
Sprache: | Englisch |
Titel: | Advanced Functional Materials |
Bandnummer: | 31 |
Heft: | 31 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | additive manufacturing cyber physical system sensor smart scaffold tissue engineering |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Tissue engineering is a systematic approach of assembling cells onto a 3D scaffold to form a functional tissue in the presence of critical growth factors. The scaffolding system guides stem cells through topological, physiochemical, and mechanical cues to differentiate and integrate to form a functional tissue. However, cellular communication during tissue formation taking place in a reactor needs to be understood properly to enable appropriate positioning of the cells in a 3D environment. Hence, sensors and actuators integrated with cyber-physical system (CPS) may be able to sense the tissue microenvironment and direct cells/cellular aggregates to an appropriate position, respectively. This can facilitate better cell-to-cell communication and cell–extracellular matrix communication for proper tissue morphogenesis. Advancements are made in the field of smart scaffolds that can morph cells/ cellular aggregates after sensing the cellular microenvironment in a desired 3D architecture by providing appropriate cues. Recent scientific developments in the additive manufacturing technology have enabled the fabrication of smart scaffolds to create structural and functional tissue constructs. Sensors/actuators, cyber-systems, smart materials, and additive manufacturing put together is expected to lead to improved tissue-engineered medical products. The present review aims to highlight the possibilities of advancement of BioCPS for tissue engineering and regenerative medicine. |
DOI der Erstveröffentlichung: | 10.1002/adfm.202009663 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/10.1002/adfm.202009663 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-368273 hdl:20.500.11880/33448 http://dx.doi.org/10.22028/D291-36827 |
ISSN: | 1616-3028 1616-301X |
Datum des Eintrags: | 14-Jul-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Orthopädie |
Professur: | M - Prof. Dr. Henning Madry |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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