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doi:10.22028/D291-40070 | Title: | Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161 |
| Author(s): | Kohr, Michael Papenkordt, Niklas Jung, Manfred Kazmaier, Uli |
| Language: | English |
| Title: | Organic & Biomolecular Chemistry |
| Volume: | 21 |
| Issue: | 21 |
| Pages: | 4382-4387 |
| Publisher/Platform: | Royal Society of Chemistry |
| Year of Publication: | 2023 |
| DDC notations: | 500 Science |
| Publikation type: | Journal Article |
| Abstract: | A novel synthesis of the naturally occurring HDAC inhibitor WF-3161 is described. Key steps include the Matteson homologation to generate the stereogenic centres in the side chain, and Pdcatalysed C–H functionalisation to connect the side chain to the peptide backbone. WF-3161 was found to be highly selective for HDAC1, whereas no activity was observed towards HDAC6. High activity was also found against the cancer cell line HL-60. |
| DOI of the first publication: | 10.1039/D3OB00641G |
| URL of the first publication: | https://pubs.rsc.org/en/content/articlelanding/2023/OB/D3OB00641G |
| Link to this record: | urn:nbn:de:bsz:291--ds-400707 hdl:20.500.11880/36079 http://dx.doi.org/10.22028/D291-40070 |
| ISSN: | 1477-0539 1477-0520 |
| Date of registration: | 5-Jul-2023 |
| Description of the related object: | Electronic supplementary information |
| Related object: | https://www.rsc.org/suppdata/d3/ob/d3ob00641g/d3ob00641g1.pdf |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Chemie |
| Professorship: | NT - Prof. Dr. Uli Kazmaier |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| d3ob00641g.pdf | 460,22 kB | Adobe PDF | View/Open |
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