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doi:10.22028/D291-28074
Title: | Quantitative, Phenotypical, and Functional Characterization of Cellular Immunity in Children and Adolescents With Down Syndrome |
Author(s): | Schoch, Justine Rohrer, Tilman R. Kaestner, Michael Abdul-Khaliq, Hashim Gortner, Ludwig Sester, Urban Sester, Martina Schmidt, Tina |
Language: | English |
Title: | The Journal of Infectious Diseases |
Volume: | 215 |
Issue: | 10 |
Startpage: | 1619 |
Endpage: | 1628 |
Publisher/Platform: | Oxford University Press |
Year of Publication: | 2017 |
Publikation type: | Journal Article |
Abstract: | Background: Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of adaptive immunity. Although the role of B cells and antibodies is well characterized, knowledge regarding T cells is limited. Methods: Lymphocyte subpopulations of 40 children and adolescents with Down syndrome and 51 controls were quantified, and phenotype and functionality of antigen-specific effector T cells were analyzed with flow cytometry after polyclonal and pathogen-specific stimulation (with varicella-zoster virus [VZV] and cytomegalovirus [CMV]). Results were correlated with immunoglobulin (Ig) G responses. Results: Apart from general alterations in the percentage of lymphocytes, regulatory T cells, and T-helper 1 and 17 cells, all major T-cell subpopulations showed higher expression of the inhibitory receptor PD-1. Polyclonally stimulated effector CD4+ T-cell frequencies were significantly higher in subjects with Down syndrome, whereas their inhibitory receptor expression (programmed cell death 1 [PD-1] and cytotoxic T-lymphocyte antigen 4 [CTLA-4]) was similar to that of controls and cytokine expression profiles were only marginally altered. Pathogen-specific immunity showed age-appropriate levels of endemic infection, with correlation of CMV-specific cellular and humoral immunity in all subjects. Among VZV IgG-positive individuals, a higher percentage of VZV-specific T-cell-positive subjects was seen in those with Down syndrome. Conclusions: Despite alterations in lymphocyte subpopulations, individuals with Down syndrome can mount effector T-cell responses with similar phenotype and functionality as controls but may require higher effector T-cell frequencies to ensure pathogen control. |
DOI of the first publication: | 10.1093/infdis/jix168 |
URL of the first publication: | https://www.ncbi.nlm.nih.gov/pubmed/28379413 |
Link to this record: | hdl:20.500.11880/27529 http://dx.doi.org/10.22028/D291-28074 |
ISSN: | 0022-1899 1537-6613 |
Date of registration: | 13-Jul-2019 |
Third-party funds sponsorship: | HOMFOR |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin |
Professorship: | M - Prof. Dr. Martina Sester M - Prof. Dr. Hashim Abdul-Khaliq |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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