Please use this identifier to cite or link to this item:
doi:10.22028/D291-27883
Title: | Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery |
Author(s): | Rey-Rico, Ana Cucchiarini, Magali |
Language: | English |
Title: | Polymers |
Volume: | 11 (2019) |
Issue: | 3 |
Publisher/Platform: | MDPI |
Year of Publication: | 2019 |
Free key words: | supramolecular hydrogels cyclodextrin-based polypseudorotaxane hydrogels controlled gene delivery nonviral vectors viral vectors gene transfer |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine. |
DOI of the first publication: | 10.3390/polym11030514 |
Link to this record: | urn:nbn:de:bsz:291--ds-278830 hdl:20.500.11880/29821 http://dx.doi.org/10.22028/D291-27883 |
ISSN: | 2073-4360 |
Date of registration: | 6-Oct-2020 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Orthopädie |
Professorship: | M - Prof. Dr. Henning Madry |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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polymers-11-00514.pdf | 1,18 MB | Adobe PDF | View/Open |
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