Please use this identifier to cite or link to this item: doi:10.22028/D291-33930
Title: Vitamin D Receptor and Vitamin D Binding Protein Gene Polymorphisms Are Associated with Renal Allograft Outcome
Author(s): Zununi Vahed, Sepideh
Ahmadian, Elham
Foroughi, Peyman
Mostafavi, Soroush
Madry, Henning
Ardalan, Mohammadreza
Cucchiarini, Magali
Language: English
Title: Nutrients
Volume: 13
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: kidney transplant
vitamin D
polymorphism
allograft rejection
viral infection
vitamin D binding protein
vitamin D receptor
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Vitamin D deficiency has adverse effects on renal allograft outcomes, and polymorphisms of genes encoding vitamin D-binding protein (VDBP) and vitamin D receptor (VDR) are defined to play a role in these conditions. The goal of the current investigation was to evaluate the connection between those polymorphisms with acute rejection, viral infection history, and recipients’ vitamin D status. In this study, 115 kidney transplant recipients and 100 healthy individuals were included. VDR polymorphisms including FokI (rs2228570), Apal (rs7975232), BsmI (rs1544410), as well as VDBP (rs7040) polymorphisms were studied using high resolution melting (PCR-HRM) analysis among the studied groups. The frequency of G allele in Apal rs7975232 polymorphism in the kidney transplant recipients was 0.63 times lower than healthy individuals (p = 0.026). Further, the G allele frequency in VDBP rs7040 polymorphism was significantly lower in patients with allograft rejection (p = 0.002). Considering the incidence of viral infection, significant differences were identified between the frequencies of VDR FokI (OR = 2.035; 95% CI 1.06–2.89, p = 0.030) and VDBP rs7040 (OR = 0.40; 95% CI 0.24–0.67, p < 0.001) T alleles in the studied groups. Moreover, the VDBP rs7040 GG genotype distribution was low in the recipients with a history of viral infection (p = 0.004). VDR (FokI) and VDBP (rs7040) alleles and their genotype distribution are significantly associated with allograft outcomes including allograft rejection and viral infection in the studied population.
DOI of the first publication: 10.3390/nu13041101
Link to this record: urn:nbn:de:bsz:291--ds-339302
hdl:20.500.11880/31259
http://dx.doi.org/10.22028/D291-33930
ISSN: 2072-6643
Date of registration: 30-Apr-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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