Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-39279
Titel: Detection Efficacy of 68Ga-PSMA-11 PET/CT in Biochemical Recurrence of Prostate Cancer with Very Low PSA Levels : A 7-Year, Two-Center “Real-World” Experience
VerfasserIn: Burgard, Caroline
Hoffmann, Manuela A.
Frei, Madita
Buchholz, Hans-Georg
Khreish, Fadi
Marlowe, Robert J.
Schreckenberger, Mathias
Ezziddin, Samer
Rosar, Florian
Sprache: Englisch
Titel: Cancers
Bandnummer: 15
Heft: 5
Verlag/Plattform: MDPI
Erscheinungsjahr: 2023
Freie Schlagwörter: prostate cancer
biochemical recurrence
low serum prostate-specific antigen (PSA) concentration
gallium-68 prostate-specific membrane antigen-11 positron emission tomography ( 68Ga-PSMA-11 PET/CT)
detection rate
PSA doubling time
Gleason score
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: In biochemical recurrence of prostate cancer (BCR), prompt tumor localization guides early treatment, potentially improving patient outcomes. Gallium-68 prostate-specific membrane antigen11 positron emission tomography/computed tomography (68Ga-PSMA-11 PET/CT) detection rates of lesions suspicious for prostate cancer are well known to rise along with prostate-specific antigen (PSA) concentration. However, published data are limited regarding very low values (≤0.2 ng/mL). We retrospectively analyzed ~7-year “real-world” experience in this setting in a large post-prostatectomy cohort (N = 115) from two academic clinics. Altogether 44 lesions were detected in 29/115 men (25.2%) (median [minimum–maximum] 1 [1–4]/positive scan). The apparent oligometastatic disease was found in nine patients (7.8%) at PSA as low as 0.03 ng/mL. Scan positivity rates were highest when PSA was >0.15 ng/mL, PSA doubling time was ≤12 months, or the Gleason score was ≥7b (in 83 and 107 patients, respectively, with available data); these findings were statistically significant (p ≤ 0.04), except regarding PSA level (p = 0.07). Given the benefits of promptly localizing recurrence, our observations suggest the potential value of 68Ga-PSMA-11 PET/CT in the very low PSA BCR setting, especially in cases with more rapid PSA doubling time or with high-risk histology.
DOI der Erstveröffentlichung: https://doi.org/10.3390/cancers15051376
URL der Erstveröffentlichung: 10.3390/cancers15051376
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-392794
hdl:20.500.11880/35410
http://dx.doi.org/10.22028/D291-39279
ISSN: 2072-6694
Datum des Eintrags: 13-Mär-2023
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Radiologie
Professur: M - Prof. Dr. Samer Ezziddin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
cancers-15-01376-v2.pdf1,84 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons