Please use this identifier to cite or link to this item:
doi:10.22028/D291-39765
Title: | Chemosensory cells in the respiratory tract as crucial regulators of innate immune responses |
Author(s): | Hollenhorst, Monika I. Krasteva-Christ, Gabriela |
Language: | English |
Title: | The Journal of Physiology |
Volume: | 601 |
Issue: | 9 |
Pages: | 1555-1572 |
Publisher/Platform: | Wiley |
Year of Publication: | 2023 |
Free key words: | airways brush cell chemosensory cell epithelium immune response solitary tuft cell Trpm5 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | During recent years chemosensory cells in extraoral tissues have been established as mediators for the detection and regulation of innate immune processes in response to pathogens. Under physiological conditions, chemosensory cells are present throughout the respiratory epithelium of the upper and lower airways as well as in the main olfactory epithelium. Additionally, they emerge in the alveolar region of the lung upon viral infections. Chemosensory cells in the upper and the lower airways detect signalling molecules from gram-positive and gram-negative bacteria as well as aeroallergens and fungi. Upon stimulation they release multiple molecules, such as the transmitter acetylcholine, the cysteinyl leukotriene E4 and the cytokine interleukin-25, which act as autocrine and paracrine signals and thereby orchestrate the innate immune responses in the respiratory system. Activation of chemosensory cells stimulates various immune cells, e.g. type 2 innate lymphoid cells, modulates mucociliary clearance and induces a protective neurogenic inflammation. This review compiles and discusses recent findings regarding chemosensory cell function in the respiratory tract. |
DOI of the first publication: | 10.1113/JP282307 |
URL of the first publication: | https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP282307 |
Link to this record: | urn:nbn:de:bsz:291--ds-397657 hdl:20.500.11880/35829 http://dx.doi.org/10.22028/D291-39765 |
ISSN: | 1469-7793 0022-3751 |
Date of registration: | 15-May-2023 |
Description of the related object: | Supporting Information |
Related object: | https://physoc.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1113%2FJP282307&file=tjp15521-sup-0001-PeerReview.pdf |
Faculty: | M - Medizinische Fakultät |
Department: | M - Anatomie und Zellbiologie |
Professorship: | M - Prof. Dr. Gabriela Krasteva-Christ |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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The Journal of Physiology - 2023 - Hollenhorst - Chemosensory cells in the respiratory tract as crucial regulators of.pdf | 4,93 MB | Adobe PDF | View/Open |
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