Please use this identifier to cite or link to this item:
doi:10.22028/D291-40852
Title: | Efficacy of ivabradine in heart failure patients with a high-risk profile (analysis from the SHIFT trial) |
Author(s): | Abdin, Amr Komajda, Michel Borer, Jeffrey S. Ford, Ian Tavazzi, Luigi Batailler, Cécile Swedberg, Karl Rosano, Giuseppe M. C. Mahfoud, Felix Böhm, Michael |
Language: | English |
Title: | ESC Heart Failure |
Volume: | 10 |
Issue: | 5 |
Pages: | 2895-2902 |
Publisher/Platform: | Wiley |
Year of Publication: | 2023 |
Free key words: | Heart failure Ivabradine Risk indicators High risk Heart rate |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Aims Early start and patient profile-oriented heart failure (HF) management has been recommended. In this post hoc analysis from the SHIFT trial, we analysed the treatment effects of ivabradine in HF patients with systolic blood pressure (SBP) < 110 mmHg, resting heart rate (RHR) ≥ 75 b.p.m., left ventricular ejection fraction (LVEF) ≤ 25%, New York Heart Association (NYHA) Class III/IV, and their combination. Methods and results The SHIFT trial enrolled 6505 patients (LVEF ≤ 35% and RHR ≥ 70 b.p.m.), randomized to ivabradine or placebo on the background of guideline-defined standard care. Compared with placebo, ivabradine was associated with a similar relative risk reduction of the primary endpoint (cardiovascular death or HF hospitalization) in patients with SBP < 110 and ≥110 mmHg [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.74–1.08 vs. HR 0.80, 95% CI 0.72–0.89, P interaction = 0.34], LVEF ≤ 25% and >25% (HR 0.85, 95% CI 0.72–1.01 vs. HR 0.80, 95% CI 0.71–0.90, P interaction = 0.53), and NYHA III–IV and II (HR 0.83, 95% CI 0.74–0.94 vs. HR 0.81, 95% CI 0.69–0.94, P interaction = 0.79). The effect was more pronounced in patients with RHR ≥ 75 compared with <75 (HR 0.76, 95% CI 0.68–0.85 vs. HR 0.97, 95% CI 0.81–0.1.16, P interaction = 0.02). When combining these profiling parameters, treatment with ivabradine was also associated with risk reductions comparable with patients with low-risk profiles for the primary endpoint (relative risk reduction 29%), cardiovascular death (11%), HF death (49%), and HF hospitalization (38%; all P values for interaction: 0.40). No safety concerns were observed between study groups. Conclusions Our analysis shows that RHR reduction with ivabradine is effective and improves clinical outcomes in HF patients across various risk indicators such as low SBP, high RHR, low LVEF, and high NYHA class to a similar extent and without safety concern. |
DOI of the first publication: | 10.1002/ehf2.14455 |
URL of the first publication: | https://doi.org/10.1002/ehf2.14455 |
Link to this record: | urn:nbn:de:bsz:291--ds-408521 hdl:20.500.11880/36705 http://dx.doi.org/10.22028/D291-40852 |
ISSN: | 2055-5822 |
Date of registration: | 26-Oct-2023 |
Description of the related object: | Supporting Information |
Related object: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fehf2.14455&file=ehf214455-sup-0001-Supplementary+Material.docx |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Prof. Dr. Michael Böhm |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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ESC Heart Failure - 2023 - Abdin - Efficacy of ivabradine in heart failure patients with a high‐risk profile analysis from.pdf | 723,44 kB | Adobe PDF | View/Open |
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