Please use this identifier to cite or link to this item: doi:10.22028/D291-41186
Title: Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review
Author(s): Dankova, Irina
Pyrgidis, Nikolaos
Tishukov, Maksim
Georgiadou, Efstratia
Nigdelis, Meletios P.
Solomayer, Erich-Franz
Marcon, Julian
Stief, Christian G.
Hatzichristou, Dimitrios
Language: English
Title: Biomedicines
Volume: 11
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: female sexual dysfunction
stress urinary incontinence
PRP injections
platelet-rich plasma
systematic review
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Introduction: There is no clear evidence in the literature that platelet-rich plasma (PRP) injections improve female sexual dysfunction (FSD) and female stress urinary incontinence (SUI). Objectives: A systematic review was performed to study the efficacy and safety of PRP injections in women with the above pathologies, as well as to explore the optimal dosing, frequency and area of injections, and duration of treatment. Methods: A systematic search on PubMed, Embase and the Cochrane Library database was performed, as well as sources of grey literature from the date of database or source creation to January 2023. After title/abstract and full-text screening, clinical studies on humans evaluating the efficacy of PRP in gynecological disorders using standardized tools were included. Risk of bias was undertaken with RoB-2 for randomized-controlled trials (RCT) and the Newcastle-Ottawa Scale (NOS) for observational studies. Results: Four prospective and one retrospective study explored FSD, while six prospective and one RCT evaluated female SUI. A total of 327 women with a mean age of 51 ± 12 years were included. For FSD, PRP significantly improved the Female Sexual Function Index (FSFI), the Vaginal Health Index (VHI) and the Female Sexual Distress score (FSDS). For SUI, PRP led to a significant improvement in the International Consultation on Incontinence Questionnaire—Short Form (ICIQ-SF) and the Urogenital Distress Inventory (UDI-6). The identified RCT reported a significantly higher mean score of ICIQ-SF (p < 0.05) and UDI-6 (p < 0.01) in the midurethral sling group compared to the PRP injections group. Regarding the risk of bias, the RCT was characterized by high risk, whereas the observational studies were of moderate risk. The protocol for PRP injections for FSD is the injection of 2 mL of PRP into the distal anterior vaginal wall once a month for 3 months. For female SUI, 5–6 mL of PRP should be injected into the periurethral area once a month for 3 months. Conclusions: Despite the promising initial results of PRP injections, the level of current evidence is low due to methodological issues in the available studies. It becomes clear that there is an emerging need for high-quality research examining PRP injections for the treatment of FSD and female SUI.
DOI of the first publication: 10.3390/biomedicines11112919
URL of the first publication: https://doi.org/10.3390/biomedicines11112919
Link to this record: urn:nbn:de:bsz:291--ds-411867
hdl:20.500.11880/36991
http://dx.doi.org/10.22028/D291-41186
ISSN: 2227-9059
Date of registration: 30-Nov-2023
Description of the related object: Supplementary Materials
Related object: https://www.mdpi.com/article/10.3390/biomedicines11112919/s1
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
Professorship: M - Prof. Dr. E.-F. Solomayer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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