Please use this identifier to cite or link to this item:
doi:10.22028/D291-41277
Title: | HLA-E and Its Soluble Form as Indicators of a Sex-Specific Immune Response in Patients with Oral Squamous Cell Carcinoma |
Author(s): | Radermacher, Anne Fehrenz, Michael Bellin, Tamara Claßen, Carolina Möller, Laura Struckmeier, Ann-Kristin Wagner, Mathias Wartenberg, Philipp Moratin, Julius Freudlsperger, Christian Freier, Kolja Horn, Dominik |
Language: | English |
Title: | International Journal of Molecular Sciences |
Volume: | 24 |
Issue: | 23 |
Publisher/Platform: | MDPI |
Year of Publication: | 2023 |
Free key words: | HLA-E soluble HLA-E oral squamous cell carcinoma (OSCC) sex-related differences in immune response immunotherapy |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman’s correlation: p = 0.002) and worse survival (Cox-regression: progression-free survival: hazard ratio (HR) 3.129, confidence range (CI) 1.443–6.787, p = 0.004; overall survival: HR 2.328, CI 1.071–5.060, p = 0.033). The sHLA-E concentration was significantly higher in the control group than in tumor group (Mann–Whitney U-test (MW-U): p = 0.021). Within the tumor group, women showed significantly higher sHLA-E levels than men (MW-U: p = 0.049). A closer look at the tumor group and the control group showed that gender-specific differences exist: while no differences in sHLA-E concentration were detectable between female subjects of tumor group and control group (MW-U: p = 0.916), male subjects of tumor group had a significantly lower sHLA-E concentration compared to those of control group (MW-U: p = 0.001). In summary, our results provide evidence for sex-specific differences in immune responses in OSCC. This fact should be considered regarding future immunotherapy regimens. |
DOI of the first publication: | 10.3390/ijms242316699 |
URL of the first publication: | https://doi.org/10.3390/ijms242316699 |
Link to this record: | urn:nbn:de:bsz:291--ds-412775 hdl:20.500.11880/37046 http://dx.doi.org/10.22028/D291-41277 |
ISSN: | 1422-0067 |
Date of registration: | 12-Dec-2023 |
Description of the related object: | Supplementary Materials |
Related object: | https://www.mdpi.com/article/10.3390/ijms242316699/s1 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Augenheilkunde M - Experimentelle und Klinische Pharmakologie und Toxikologie M - Pathologie M - Zahn-, Mund- und Kieferheilkunde |
Professorship: | M - Prof. Dr. Ulrich Boehm M - Prof. Dr. Kolja Freier M - Prof. Dr. Berthold Seitz M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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ijms-24-16699.pdf | 1,49 MB | Adobe PDF | View/Open |
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