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doi:10.22028/D291-41529
Titel: | ArthroRad trial: randomized multicenter single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis-final results after 12-month follow-up |
VerfasserIn: | Niewald, Marcus Moumeniahangar, Sobhan Müller, Lara N. Hautmann, Matthias G. Dzierma, Yvonne Fleckenstein, Jochen Gräber, Stefan Rübe, Christian Hecht, Markus Melchior, Patrick |
Sprache: | Englisch |
Titel: | Strahlentherapie und Onkologie |
Bandnummer: | 200 (2024) |
Heft: | 2 |
Seiten: | 134-142 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2023 |
Freie Schlagwörter: | Osteoarthritis Low-dose radiotherapy Pain KOOS-PS SF-SACRAH |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Objective Updated report about the randomized comparison of the effect of radiotherapy on painful osteoarthritis (OA) applying a standard dose vs. a very low dose regime after a follow-up of 1 year. Patients and methods Patients presenting with OA of the hand/finger and knee joints were included. After randomization (every joint region was randomized separately) the following protocols were applied: (a) standard arm: total dose 3.0 Gy, single fractions of 0.5 Gy twice a week; (b) experimental arm: total dose 0.3 Gy, single fractions of 0.05 Gy twice a week. The dosage was blinded for the patients. For evaluation the scores after 1-year visual analog scale (VAS), Knee Injury and Osteoarthritis Outcome Score–Short Form (KOOS-PS), Short Form Score for the Assessment and Quantification of Chronic Rheumatic Affections of the Hands (SF-SACRAH) and 12-item Short-Form Health Survey (SF-12) were used (for further details: see [1]). Results The standard dose was applied to 77 hands and 33 knees, the experimental dose was given to 81 hands and 30 knees. After 12 months, the data of 128 hands and 45 knees were available for evaluation. Even after this long time, we observed a favorable response of pain to radiotherapy in both trial arms; however, there were no reasonable statistically significant differences between both arms concerning pain, functional, and quality of life scores. Side effects did not occur. The only prognostic factor was the pain level before radiotherapy. Conclusions We found a favorable pain relief and a limited response in the functional and quality of life scores in both treatment arms. The possible effect of low doses such as 0.3 Gy on pain is widely unknown. |
DOI der Erstveröffentlichung: | 10.1007/s00066-023-02152-z |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00066-023-02152-z |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-415295 hdl:20.500.11880/37202 http://dx.doi.org/10.22028/D291-41529 |
ISSN: | 1439-099X 0179-7158 |
Datum des Eintrags: | 30-Jan-2024 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Radiologie |
Professur: | M - Prof. Dr. Markus Hecht M - Prof. Dr. Christian Rübe M - Prof. Dr. Joachim Oertel |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s00066-023-02152-z.pdf | 350,24 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons