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doi:10.22028/D291-41745
Title: | Redo nephron-sparing surgery in stage V pediatric renal tumors - A report from the SIOP/GPOH study group for renal tumors |
Author(s): | Fuchs, Jörg Schunn, Matthias C. Schäfer, Jürgen F. Ebinger, Martin Graf, Norbert Furtwängler, Rhoikos Warmann, Steven W. |
Language: | English |
Title: | European Journal of Surgical Oncology |
Volume: | 50 (2024) |
Issue: | 1 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2023 |
Free key words: | Nephroblastoma Nephron-sparing surgery Tumor relapse |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Purpose Nephron-sparing Surgery (NSS) is the surgical treatment of choice in children with bilateral renal tumors or in syndromatic patients. With an increasing role of this surgical approach, there is also an increased number of tumor relapses after NSS. Aim of this study was to evaluate a second (“Redo-“) NSS in children with relapsed renal tumors. Materials and methods We retrospectively analysed patients undergoing Redo-NSS for relapsed kidney tumors between 2009 and 2021 at our institution, which represents a national reference center of the SIOP/GPOH renal tumor study group. Results Nine patients (5 girls, 4 boys) underwent Redo-NSS with resection of 15 lesions. Mean age at surgery was 58 months (12-137), mean operative time for Redo-NSS was 195 min (137-260). R0 resection status was achieved in all children. Two patients had second relapses, one of them was resected via NSS, the other child underwent tumor nephrectomy. Two patients with anaplastic relapses died from combined second relapses. Thus, 7/9 patients are alive without evidence of disease, an impaired renal function was observed in one child. Mean follow-up after Redo-NSS was 35 months (6-49). Conclusions In renal tumor relapses, Redo-NSS can be performed with satisfactory oncological and functional results. Occurrence of diffuse anaplasia should possibly refrain from this approach. Further evaluation in international multicenter analyses are necessary for a definitive determination of Redo-NSS. |
DOI of the first publication: | 10.1016/j.ejso.2023.107265 |
URL of the first publication: | https://doi.org/10.1016/j.ejso.2023.107265 |
Link to this record: | urn:nbn:de:bsz:291--ds-417452 hdl:20.500.11880/37360 http://dx.doi.org/10.22028/D291-41745 |
ISSN: | 0748-7983 |
Date of registration: | 13-Mar-2024 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Pädiatrie |
Professorship: | M - Prof. Dr. Norbert Graf |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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