Please use this identifier to cite or link to this item:
doi:10.22028/D291-41776
Title: | Unusual Case of Splenic Metastasis in Adenosquamous Carcinoma of the Cervix Uteri: Diagnosis and Treatment Considerations |
Author(s): | Klamminger, Gilbert Georg Burgard, Caroline Rosar, Florian Altmeyer, Katrin Malinowski, Maciej Nigdelis, Meletios P. Stahl, Phillip Rolf Solomayer, Erich Franz Haj Hamoud, Bashar |
Language: | English |
Title: | The American Journal of Case Reports |
Volume: | 24 |
Publisher/Platform: | International Scientific Information |
Year of Publication: | 2023 |
Free key words: | Uterine Cervical Neoplasms Spleen Neoplasm Metastasis |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | BACKGROUND: Due to several factors such as its specific cellular and biochemical microenvironment, the spleen is not a predestined organ of frequent metastatic colonization in the case of primary solid carcinoma. Hence, the mode of diagnosis and the preferred treatment of a lesion highly suspicious of splenic metastasis must be decided on a case-by-case basis, considering not only the biological tumor entity but also the stage of the primary disease. CASE REPORT: In the present case, we demonstrate the clinical course of a 37-year-old female patient who initially presented to our clinic with irregular vaginal bleeding. A consecutive gynecological examination revealed a 3×3-cm large mass of the cervix uteri, and the subsequent histomorphological workup led to the diagnosis of an adenosquamous carcinoma of the cervix uteri. Therapeutically, the patient received multimodal treatment, namely radical hysterectomy with adjuvant radio-chemotherapy. After 1.5 years, the patient presented to our Emergency Department with intermittent left-sided abdominal pain. Subsequent abdominal imaging (computed tomography scan, magnetic resonance imaging, positron emission tomography) determined a metabolically active splenic lesion with a central necrosis – signs of malignancy in line with a splenic metastasis. Presentation and discussion of the case within our interdisciplinary tumor board led to the decision of splenectomy followed by chemotherapy, a procedure that could be considered as therapeutic treatment in such exceptional cases. CONCLUSIONS: The collection and reporting of atypical clinical courses remains a key factor in precision medicine to enable the most evidence-based decision making in such cases. |
DOI of the first publication: | 10.12659/AJCR.941600 |
URL of the first publication: | https://amjcaserep.com/abstract/full/idArt/941600 |
Link to this record: | urn:nbn:de:bsz:291--ds-417760 hdl:20.500.11880/37382 http://dx.doi.org/10.22028/D291-41776 |
ISSN: | 1941-5923 |
Date of registration: | 19-Mar-2024 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Frauenheilkunde M - Pathologie M - Radiologie |
Professorship: | M - Prof. Dr. Rainer M. Bohle M - Prof. Dr. E.-F. Solomayer M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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941600.pdf | 1,93 MB | Adobe PDF | View/Open |
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