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doi:10.22028/D291-41250
Title: | Design of a Biohybrid Materials Circuit with Binary Decoder Functionality |
Author(s): | Mohsenin, Hasti Wagner, Hanna J. Rosenblatt, Marcus Kemmer, Svenja Drepper, Friedel Huesgen, Pitter Timmer, Jens Weber, Wilfried |
Language: | English |
Publisher/Platform: | bioRxiv |
Year of Publication: | 2023 |
DDC notations: | 570 Life sciences, biology |
Publikation type: | Other |
Abstract: | Synthetic biology applies concepts from electrical engineering and information processing to endow cells with computational functionality. Transferring the underlying molecular components into materials and wiring them according to topologies inspired by electronic circuit boards has yielded materials systems that perform selected computational operations. However, the limited functionality of available building blocks is restricting the implementation of advanced information-processing circuits into materials. Here, we engineer a set of protease-based biohybrid modules the bioactivity of which can either be induced or inhibited. Guided by a quantitative mathematical model and following a design-build-test-learn cycle, we wire the modules according to circuit topologies inspired by electronic signal decoders, a fundamental motif in information processing. We design a 2-input/4-output binary decoder for the detection of two small molecules in a material framework that could perform regulated outputs in form of distinct protease activities. The here demonstrated smart material system is strongly modular and could be used for biomolecular information processing for example in advanced biosensing or drug delivery applications. |
DOI of the first publication: | 10.1101/2023.08.10.552766 |
URL of the first publication: | https://www.biorxiv.org/content/10.1101/2023.08.10.552766v2 |
Link to this record: | urn:nbn:de:bsz:291--ds-412501 hdl:20.500.11880/37501 http://dx.doi.org/10.22028/D291-41250 |
Date of registration: | 19-Apr-2024 |
Notes: | Preprint |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Materialwissenschaft und Werkstofftechnik |
Professorship: | NT - Prof. Dr. Wilfried Weber |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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