Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-41963
Titel: TRPC3 Is Downregulated in Primary Hyperparathyroidism
VerfasserIn: Kirstein, Emilie
Schaudien, Dirk
Wagner, Mathias
Diebolt, Coline M.
Bozzato, Alessandro
Tschernig, Thomas
Englisch, Colya N.
Sprache: Englisch
Titel: International Journal of Molecular Sciences
Bandnummer: 25
Heft: 8
Verlag/Plattform: MDPI
Erscheinungsjahr: 2024
Freie Schlagwörter: TRPC3
TRPC6
CaSR
parathyroid gland
primary hyperparathyroidism
human
immunohistochemistry
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Transient receptor potential canonical sub-family channel 3 (TRPC3) is considered to play a critical role in calcium homeostasis. However, there are no established findings in this respect with regard to TRPC6. Although the parathyroid gland is a crucial organ in calcium household regulation, little is known about the protein distribution of TRPC channels—especially TRPC3 and TRPC6—in this organ. Our aim was therefore to investigate the protein expression profile of TRPC3 and TRPC6 in healthy and diseased human parathyroid glands. Surgery samples from patients with healthy parathyroid glands and from patients suffering from primary hyperparathyroidism (pHPT) were investigated by immunohistochemistry using knockout-validated antibodies against TRPC3 and TRPC6. A software-based analysis similar to an H-score was performed. For the first time, to our knowledge, TRPC3 and TRPC6 protein expression is described here in the parathyroid glands. It is found in both chief and oxyphilic cells. Furthermore, the TRPC3 staining score in diseased tissue (pHPT) was statistically significantly lower than that in healthy tissue. In conclusion, TRPC3 and TRPC6 proteins are expressed in the human parathyroid gland. Furthermore, there is strong evidence indicating that TRPC3 plays a role in pHPT and subsequently in parathyroid hormone secretion regulation. These findings ultimately require further research in order to not only confirm our results but also to further investigate the relevance of these channels and, in particular, that of TRPC3 in the aforementioned physiological functions and pathophysiological conditions.
DOI der Erstveröffentlichung: 10.3390/ijms25084392
URL der Erstveröffentlichung: https://doi.org/10.3390/ijms25084392
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-419635
hdl:20.500.11880/37556
http://dx.doi.org/10.22028/D291-41963
ISSN: 1422-0067
Datum des Eintrags: 29-Apr-2024
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Anatomie und Zellbiologie
M - Hals-Nasen-Ohrenheilkunde
M - Pathologie
Professur: M - Prof. Dr. Carola Meier
M - Prof. Dr. Bernhard Schick
M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
ijms-25-04392-v2.pdf1,56 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons