Please use this identifier to cite or link to this item:
-no DOI; please use other URI| Title: | Synthesis of a Conformationally Fixed Bicyclomarin Derivative |
| Author(s): | Greve, Jennifer Kiefer, Alexander F. Kazmaier, Uli |
| Language: | English |
| Title: | ChemMedChem |
| Volume: | 20 |
| Issue: | 21 |
| Publisher/Platform: | Wiley |
| Year of Publication: | 2025 |
| Free key words: | clpC1 cyclomarin cyclopeptides macrolactamizations tuberculosis |
| DDC notations: | 500 Science |
| Publikation type: | Journal Article |
| Abstract: | Based on an X-ray structure of cyclomarin bound to ClpC1, a new conformationally fixed, bicyclic cyclomarin derivative is synthesized in an effort to enhance antituberculosis activity. The synthesis of the linear heptapeptide and the two macrolactamizations proceed smoothly. Only the very last synthetic step, the cleavage of a benzyl ether, provides a low yield. Despite the successful synthesis, the resulting bicyclic compound shows reduced activity compared to cyclomarin. |
| DOI of the first publication: | 10.1002/cmdc.202500493 |
| URL of the first publication: | https://doi.org/10.1002/cmdc.202500493 |
| Link to this record: | urn:nbn:de:bsz:291--ds-468934 hdl:20.500.11880/41079 |
| ISSN: | 1860-7187 1860-7179 |
| Date of registration: | 6-Feb-2026 |
| Description of the related object: | Supporting Information |
| Related object: | https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fcmdc.202500493&file=cmdc70047-sup-0001-SuppData-S1.pdf |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Chemie |
| Professorship: | NT - Prof. Dr. Uli Kazmaier |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
| File | Size | Format | |
|---|---|---|---|
| ChemMedChem - 2025 - Greve - Synthesis of a Conformationally Fixed Bicyclomarin Derivative.pdf | 558,04 kB | Adobe PDF | View/Open |
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